p-Aminobenzoic Acid as a New Reagent in Spectrophotometric Determination of Salbutamol Sulphate Via Oxidative Coupling Reaction

Authors

  • Nabeel S. Othman University of Mosul

DOI:

https://doi.org/10.1115/italienisch.v11i2.115

Keywords:

spectrophotometry, salbutamol sulphate, p-aminobenzoic acid, oxidative coupling reaction, N-chlorosuccinimide

Abstract

A simple spectrophotmetic method for the determination of salbutamol sulphate (SBS) in aqueous solution has been suggested. The method is based on the oxidative coupling reaction of SBS with p-aminobenzoic acid (PABA) in an alkaline medium (pH=11.96) in presence of N-chlorosuccinimide (NCS) as oxidizing agent to produce an intense blue colored, water soluble and stable product, which showed maximum absorption at 622 nm. Beers law is obeyed over the range2.0 - 25.0 g. ml-1 of SBS and limit of detection (LOD) of 0.460 g. ml-1, limit of quantitation (LOQ) of 1.536 g. ml-1, a molar absorptivity of 1.828104 l. mol-1. cm-1. and Sandells sensitivity index of 0.0315 g. cm-2. The method has been successfully applied to the determination of SBS in pharmaceutical preparations.

Published

2021-07-06

How to Cite

Nabeel S. Othman. (2021). p-Aminobenzoic Acid as a New Reagent in Spectrophotometric Determination of Salbutamol Sulphate Via Oxidative Coupling Reaction. I T A L I E N I S C H, 11(2), 264–270. https://doi.org/10.1115/italienisch.v11i2.115